BC Cancer Agency
BCCA

Brad Nelson

Toward personalized immunotherapy: identifying tumour-specific factors that dictate the response of spontaneous mammary cancers to T cells

Breast

Spencer Martin

Development of personalized vaccines targeting tumour-specific mutations

Melanoma of skin All cancers but non-melanoma skin cancer

Wan Lam

Understanding the mechanisms of lung cancer development in never smokers

Trachea, bronchus and lung

David Twa

The significance of recurrent translocations involving programmed death ligands in non-Hodgkin lymphomas

Non-Hodgkin lymphoma

Shoukat Dedhar

The Role of Tumor Microenvironment in Cancer Progression: Identification and Therapeutic Intervention of Novel Targets

Melanoma of skin All cancers but non-melanoma skin cancer

Isabella Tai

The Role of SPARC in Cancer Therapy Sensitization

Melanoma of skin All cancers but non-melanoma skin cancer

Angel Chia-Yu Yu

The role of NPM1 in apoptosis resistance in colorectal cancer

Colorectum

Poul Sorensen

The Hace1 tumour suppressor--a novel regulator of the oxidative stress response

Kidney, renal pelvis and ureter

Pediatric oncology or childhood cancer

Stephen Choi

Targeting monocarboxylate transporter 4 (MCT4) for treatment of castration resistant prostate cancer (CRPC)

Prostate

Joseph Lau

Targeting Carbonic Anhydrase IX and Hypoxia for the Diagnosis and Treatment of Aggressive Breast Cancers

Breast

Shoukat Dedhar

Targeting Carbonic Anhydrase IX and Hypoxia for the diagnosis and treatment of aggresive breast cancers

Breast

Gregg Morin

Recurrent Somatic DICER1 Mutations: Functional Implication and Role in Oncogenesis

Melanoma of skin All cancers but non-melanoma skin cancer

Jithendra Gunawardana

Recurrent IL4R mutations in Primary Mediastinal Large B Cell Lymphoma

Non-Hodgkin lymphoma Hodgkin lymphoma

Calum Macaulay

Real-Time In Vivo Oral Pathology for Clinical Decision Making

Lip, oral cavity

Pathology

Mary Mcbride

Phase-Specific and Lifetime Medical Costs of Care for Childhood Cancer in British Columbia and Ontario

Melanoma of skin All cancers but non-melanoma skin cancer

Pediatric oncology or childhood cancer

Yuzhuo Wang

Next generation patient-derived, genetically-defined prostate cancer xenograft models for anti- cancer drug development

Prostate

Yuzhuo Wang

Next generation patient-derived, genetically-defined kidney and bladder cancer xenograft models for anti-cancer drug development

Kidney, renal pelvis and ureter Bladder

Greg Stewart

New mechanisms driving non-small cell lung cancer

Trachea, bronchus and lung

Calum Macaulay

Multi-Scale Tissue System's Biology approach to Identify Lethal Prostate Cancer

Prostate

Pathology

Catherine Enfield

MicroRNAs as modulators of lung cancer targeted therapy and novel predictors of drug response

Trachea, bronchus and lung

Reka Pataky

Methods for the economic evaluation of personalized medicine: a case study in advanced colorectal cancer

Colorectum

Samuel Aparicio

Linking clonal genomes to tumour evolution and therapeutics

Melanoma of skin All cancers but non-melanoma skin cancer

Haishan Zeng

Integrated In Vivo Multiphoton Microscopy and Confocal Raman Spectroscopy for Skin Cancer Detection and Evaluation

Melanoma of skin Non-Melanoma skin cancer

Marcel Bally

Identifying Cytoprotective Responses Triggered Following Initial Exposure to Targeted Therapy: Defining Improved Treatment Strategies for Patients with HER-2 Positive Breast Cancer

Breast

Hanyang Lin

Identification of new microRNA biomarkers and candidate target genes in primitive CML cells using global comparative RNA analyses

Leukaemia

Helen Mctaggart-Cowan

General Public's Perception of a Quality-adjusted Life Year in Cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Marco Marra

Exploring the relationship between the genome and the epigenome in cancers

Melanoma of skin All cancers but non-melanoma skin cancer

Shoukat Dedhar

Development of therapeutic antibodies targeting carbonic anhydrase IX (CAIX)

Breast

Fang Wang

Defining the role of human isomiR-181a in myelodysplastic syndromes

Melanoma of skin All cancers but non-melanoma skin cancer

Reka Pataky

Comparing five-year and lifetime costs of cancer care in British Columbia and Ontario: phase-based costing with linked administrative data in two Canadian provinces

Melanoma of skin All cancers but non-melanoma skin cancer

Wan Lam

An integrative approach to understand lung cancer development in smokers and non-smokers

Trachea, bronchus and lung

Pathology

Peter Stirling

Understanding and exploiting genome instability in cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Robert Kridel

The pathogenic role of tumor-associated macrophages in Hodgkin lymphoma

Hodgkin lymphoma

Pathology

David Huntsman

The Genetics of Hereditary Upper Gastrointestinal Cancers: Beyond CDH1 Germline Mutations

Stomach Pancreas Oesophagus Colorectum

Pathology

Svetlana Bortnik

The effects of autophagy knockdown in breast cancer cells using in vivo xenograft models

Breast

Sohrab Shah

The clonal dynamics of ovarian cancers: phylogenetic models of chemosensitivity and resistance

Ovary

Pathology

Poul Sorensen

Targeting the tumour cell stress response in high-risk childhood cancers

Melanoma of skin All cancers but non-melanoma skin cancer

Pediatric oncology or childhood cancer

Xiaoyan Jiang

Targeting Drug-Insensitive CML Stem Cells with Combination Therapy of New ABL and PP2A Inhibitors

Leukaemia

Andrew Roth

Studying The Evolution Of Cancer Genomes

Melanoma of skin All cancers but non-melanoma skin cancer

Scott Tyldesley

Strategic configuration of cancer care services based on clinical, demographic and geographic considerations

Melanoma of skin All cancers but non-melanoma skin cancer

Christian Steidl

Somatic mutations in the JAK-STAT signaling pathway in primary mediastinal large B cell lymphoma

Non-Hodgkin lymphoma Hodgkin lymphoma

Linda Ya-Ting Chang

Role of innate immune signaling in myelodysplastic syndromes

Leukaemia

Louis-Bastien Weiswald

Role of CDK10 in colorectal cancer

Colorectum

Marianne Sadar

Reversible inhibitors of the N-terminal domain of the androgen receptor

Colorectum

Andrew Weng

Regulation of Leukemia Stem Cell Activity by Signaling through PKC[theta]

Leukaemia

Paul Miller

Regulation of human hematopoietic cells with rapid in vivo repopulating activity

Leukaemia

Kevin Bennewith

Promotion of breast cancer metastasis by tumour hypoxia and myeloid cells

Breast

Christian Steidl

Prognostic markers and biology of relapsed Hodgkin lymphoma

Hodgkin lymphoma

Samuel Aparicio

PP2a protein serine/threonine phosphatase mutations in cancer: functional consequences and clinical relevance

Ovary Corpus uteri Breast

Kuo-Shyan Lin

PET tracers for imaging bradykinin B1 receptor expression in cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Joseph Connors

Personalized Treatment of Lymphoid Cancer: British Columbia as Model Province

Non-Hodgkin lymphoma Hodgkin lymphoma

Calum Macaulay

Optically-Guided Biopsy for Improved Diagnosis of Peripheral Pulmonary Nodules

Trachea, bronchus and lung

Catherine Jenkins

Oncogenic collaboration between RUNX and Notch in T-cell leukemia

Leukaemia

Bo Rafn

Oncogene-induced ROS as a driver of tumorigenesis and transformation

Melanoma of skin All cancers but non-melanoma skin cancer

Melissa Mcconechy

Mutational and Functional Analysis of PPP2R1A in High Risk Endometrial Carcinomas

Corpus uteri

Xiaoyan Jiang

Molecular Targeting of Critical Domains of AHI-1 Oncoprotein in Chronic Myeloid Leukemia Stem Cells Resistant to Current Tyrosine Kinase Inhibitor Therapy

Leukaemia

Andrew Minchinton

Metabolic manipulation of hypoxia and radiotherapy response

Melanoma of skin All cancers but non-melanoma skin cancer

Peter Stirling

Mechanisms of genome instability induced by RNA splicing defects

Leukaemia

William Lockwood

Longitudinal assessment of immune-tumor interactions during lung cancer progression

Trachea, bronchus and lung

Marcel Bally

Lipid-based nanopharmaceuticals alone and in combination to treat aggressive forms of cancer: Design and development of formulations capable of causing tumor specific blood vessel damage

Melanoma of skin All cancers but non-melanoma skin cancer

Scott Brown

Interrogating large-scale cancer genome datasets to aid in the development of personalized cancer immunotherapies.

Melanoma of skin All cancers but non-melanoma skin cancer

Chengcheng Zhang

In vitro and in vivo evaluation of a novel 68Ga-labeled BVD15 analogue for neuropeptide Y1 receptor imaging with positron emission tomography

Breast

Radiation Oncology

Yuzhuo Wang

Identification of miRNAs and their Specific Gene Targets that are Critical for Prostate Cancer Metastases

Prostate

Shing Zhan

Identification of drivers of metastasis in Ewing sarcoma using next-generation sequencing technologies

Sarcoma

Inanc Birol

High throughput analysis of RNA-seq reads to characterize alternative polyadenylation in myeloid malignancy

Leukaemia

Sohrab Shah

Genomic Disruption in High-Grade Serous Ovarian Carcinomas: Steady State or Continuous Drift?

Ovary

Pamela Hoodless

Epigenetic Modifications Regulating Hepatocellular Carcinoma and Hepatocyte Differentiation

Liver and intrahepatic bile ducts

Rita Rebollo Figueiredo Da Sil

Epigenetic deregulation of transposable elements contributes to Hodgkin lymphoma microenvironment formation

Hodgkin lymphoma

Emilia Lim

Elucidating the Mechanisms by which Mutations in Histone Modifying Genes Contribute to Lymphomagenesis

Non-Hodgkin lymphoma Hodgkin lymphoma

Christian Steidl

Biology and clinical significance of the tumour microenvironment in lymphoid cancers

Non-Hodgkin lymphoma Hodgkin lymphoma

Pathology

Francois Benard

Advancing the clinical development of [18F]AMBF3-TATE, a novel imaging probe for neuroendocrine tumours

Melanoma of skin All cancers but non-melanoma skin cancer

Andrew Weng

Adult vs. Fetal Programs in Leukemia Pathogenesis

Leukaemia

Pathology Pediatric oncology or childhood cancer