Institute of Cancer Research
ICR

Nazneen Rahman

Using Genetics in Mainstream Medicine to Deliver Personalised Care for Cancer Patients.

Ovary Breast

Dale Wigley

A facility for in-house analysis and X-ray data collection of crystals with large subunit cells.

Melanoma of skin All cancers but non-melanoma skin cancer

Radiation Oncology

Hannah Wang

Understanding the HSF1 pathway and its potential for cancer therapy

Melanoma of skin All cancers but non-melanoma skin cancer

Dale Wigley

Understanding the structure and mechanism of macromolecular machines that regulate chromatin dynamics

Melanoma of skin All cancers but non-melanoma skin cancer

Alan Ashworth

The Development of First Time in Human (FTIH), Orally Bioavailable, Small Molecule Tankyrase Inhibitors for the Treatment of Cancer

Colorectum

Florian Stengel

The assembly mechanism of higher order protein assemblies

Melanoma of skin All cancers but non-melanoma skin cancer

Alice Hooper

Synthesis and biological evaluation of CRAF inhibitors

Melanoma of skin All cancers but non-melanoma skin cancer

Christopher Tape

Quantitative proteomic dissection of genetic aberrations In PDAC development

Pancreas

Pathology

Caroline Springer

Preclinical and Clinical Development of BRAF Inhibitors

Melanoma of skin

Caroline Springer

Late Stage Lead Optimisation, Preclinical Development and Clinical Trial of Lysyl Oxidase (LOX) Inhibitors

Melanoma of skin All cancers but non-melanoma skin cancer

Samuel Jones

Investigation of Tankyrase Inhibitors to Block Wnt Signalling as a TherapeuticStrategy for Sarcomas

Sarcoma

Julian Downward

Investigation of circulating tumour DNA in the early detection of KRAS and EGFR mutant cancers

Melanoma of skin All cancers but non-melanoma skin cancer

Ewan Smith

Identifying the molecular targets of inhibitors of androgen receptor mediated transcription by photoaffinity labelling

Melanoma of skin All cancers but non-melanoma skin cancer

Anastasia Constantinidou

Identification of genes involved in the differentiation of liposarcomas as novel therapeutic targets

Sarcoma

Nazneen Rahman

Genetic and epigenetic investigations of childhood cancer and overgrowth syndromes

Melanoma of skin All cancers but non-melanoma skin cancer

Pediatric oncology or childhood cancer

Meera Nandhabalan

Exploiting the contributions of PI3-kinase signalling and EZH2 histone methyltransferase to drug resistance and tumorigenesis in glioblastoma

Brain, nervous system

Pediatric oncology or childhood cancer

Mel Greaves

Evolutionary biology of cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Pathology

James Mui

Design and synthesis of small molecule inhibitors of NEK family Ser/Thr protein kinases

Melanoma of skin All cancers but non-melanoma skin cancer

Stuart Rankin

Design and synthesis of medium-ring compounds to target nucleotide binding sites

Melanoma of skin All cancers but non-melanoma skin cancer

Liam Hudson

Design and synthesis of Histone Lysine Methyltransferases inhibitors as epigenetic modulators

Melanoma of skin All cancers but non-melanoma skin cancer

Lorna Suckling

Addiction to chaperones: Probing the role of HSP70 isoforms in cancer cells

Melanoma of skin All cancers but non-melanoma skin cancer

Elizabeth Cullis

Therapeutic Targeting of ALK in Neuroblastoma

Brain, nervous system

Pediatric oncology or childhood cancer

Joaquin Mateo Valderrama

Predictive biomarkers of response to DNA repair targeting agents in sporadic prostate cancer

Prostate

Ben O'Leary

MICA: Using circulating tumour DNA to identify and predict mechanisms of resistance to targeted cancer therapies

Breast

Pathology

Pascal Meier

Harnessing TNF-mediated cell death in cancer

Melanoma of skin All cancers but non-melanoma skin cancer

Martin Leach

Evaluation of non-invasive metabolic imaging biomarkers for novel RAF/MEK1/2-targeted anti-cancer agents

Melanoma of skin

Investigator from Institute of Cancer Research

Structural basis of Cullin-RING ligase regulation by the COP9 signalosome

Melanoma of skin All cancers but non-melanoma skin cancer

Demetrius Albanes

Vitamin D Pooling Project of Breast and Colorectal Cancer

Colorectum Breast

Louise Brinton

Male Breast Cancer Pooling Project

Breast

Mark Greene

International Testicular Cancer Linkage Consortium

Testis

Pathology

Javed Khan

Identification of Genes for Predicting Prognosis in Pediatric Cancers

All cancers but non-melanoma skin cancer

Pediatric oncology or childhood cancer

Katherine Warren

Establishment of an International DIPG Registry

Brain, nervous system

Pediatric oncology or childhood cancer

Robert Hoover

Cohort Consortium

Prostate Breast

Laura A Johnston

An innate system for detection of aberrant tissue growth

All cancers but non-melanoma skin cancer

Eun-Sil S Hwang

(PQC3) Genomic Diversity and Microenvironment as Drivers of Metastasis in DCIS

Breast

John M Maris

The Genetic Basis of Neuroblastoma Tumorigenesis

Brain, nervous system

Pediatric oncology or childhood cancer

Targeting BCL6 in Tyrosine Kinase-Driven Leukemia

Leukaemia

Hematology and hematologic malignancies Pathology

Targeted Epigenetic Therapy of Triple-Negative Breast Cancer

Breast

Stephen N Thibodeau

Prostate Cancer Susceptibility: The ICPCG Study

Prostate

Pathology

Cory Abate-Shen

Preclinical Analyses of Advanced Prostate Cancer in Genetically-Engineered Mice

Prostate

Pathology

Katherine L Nathanson

Post GWA Studies in Testicular Germ Cell Tumors

Testis

Pathology

Melissa L Bondy

International Case Control Study of Malignant Glioma

Brain, nervous system