In a recent study, scientists at the Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB) in Kerala, have devised a new approach that can edit genetic sequences, in cervical cancer cells that can knock out the cancer-causing gene and thus, serve as an alternative therapeutic approach in treating cervical cancer.
Human Papilloma Virus (HPV) is one of causative agents of cervical cancer in women. While most infections caused by HPV clear up on their own, many women, with persistent HPV infections, gradually develop cervical cancer. According to a study, India accounts for one-third of the cervical cancer deaths globally.
Among the two genetic sequences (genotypes) of the virus -- HPV-16 and HPV-18 -- that cause cancer, HPV-16 is the most prevalent gene in India. The recent study, published in Nature’s journal Scientific Reports, the researchers have used a gene editing molecule that can edit the protein producing gene E7, found in HPV, and has a role in causing cervical cancer and making it malignant.