The Aboriginal Nurses Association of Canada (A.N.A.C.) proposes to host a one-day interactive workshop that brings together national indigenous and non-indigenous organizations and researchers as active participants in the design of a self-determining multi-disciplinary and generative model for the development of effective and equitable health partnerships with indigenous communities. Our goal is to identify and articulate principles, protocols and mechanisms that assist stakeholders in the application of culturally relevant leading practices in health policy, education and research, programs and services for First Nations, Inuit, and Metis populations in Canada. The contexts of health equity and chronic diseases, such as diabetes, cardiovascular disease and cancer, will provide the framework and focus for discussion that aims to identify best and/or most promising approaches to initiate and form successful health partnerships with FNIM people, as grounded in indigenous communitarian ethos, traditions and experience . The interactive discussions will generate input from experienced audience members who will assist defining these essential elements. The outcome of this will be to put forward a culturally relevant model that can be adapted to multi-disciplinary approaches. This event marks proposed activity for A.N.A.C. and other national indigenous health organizations to come together as leaders and catalysts to support health partnerships for the improved health and wellness of FNIM communities. Merging multi-jurisdictional boundaries and health disciplines, in this way, promises to support health partnerships.