Dr. Singh's research program applies a developmental neurobiology framework to the study of brain tumours. Her Canada Research Chair has capitalized on her previous discovery of an abnormal stem cell that drives brain tumour formation (the brain tumour initiating cell, or BTIC). The Chair has fostered innovative, highly specialized projects that have permitted a functional characterization of stem cell signaling pathways that are disrupted in BTICs. Dr. Singh is currently studying the regulation of BTIC signaling pathways in glioblastoma, brain metastases and childhood medulloblastoma, with an ultimate goal of selectively targeting the BTIC with appropriately tailored drug and molecular therapies.