The success of the Population-based Research Optimizing Screening through Personalized Regimens(PROSPR) program critically relies on a highly talented and committed PROSPR Statistical CoordinatingCenter (PSCC) to coordinate the research of PROSPR Research Centers (PRCs) to achieve PROSPR'smission of evaluating and improving the cancer screening process (recruitment, screening, diagnosis, andreferral for treatment). This PSCC application is from a team of investigators with extensive experience instatistics, data and coordinating center management, and research focused on the screening of breast,colon, and cervical cancers at the Fred Hutchinson Cancer Research (FHCRC) and University ofWashington (UW), built upon the infrastructure and expertises from three large NCI-funded coordinatingcenters over multiple funding cycles: the Early Detection Research Network (EDRN), Breast CancerSurveillance Consortium (BCSC), and the Transdisciplinary Research on Energetics and Cancer (TREC)Consortium.The overall objectives of the PSCC are to be accomplished by 1) Providing logistic support for PROSPRmeetings and enhance communications and collaborations via a secure PROSPR web portal and adedicated operations team; 2) Providing scientific, clinical, and statistical leadership to enhance PROSPR'sscientific vigor and productivity via three organ specific PSCC working groups with the extensive expertise instatistics, clinics, and epidemiology; 3) Providing study design, data collection, and data managementexpertise to enable appropriate pooling of data from studies across PRCs and to lead trans-network crossorgan site studies via a statistical team with extensive experience in developing new statistical methodologyand in designing and analyzing data for screening studies; 4) Providing statistical consultations for PRCsand lead data analyses for pooled PROSPR studies and trans-network studies; and 5) Serving as a resourceto the scientific community for dissemination and outreach of PROSPR data and findings via a PROSPRpublic portal.RELEVANCE (See instructions):Improving screening process for breast, colon, and cervical cancers will reduce mortality, motbidity, andhealth care cost associated with these cancers in US.