The Scale-Up project seeks to reduce cervical cancer incidence through improved and expanded screening using HPV DNA testing. This will be achieved through three primary outcomes: 1) Adoption of HPV DNA testing as the primary screening mechanism for detecting cervical precancer and cancer in Central American countries, 2) Establishment of a regional procurement system to secure access to diagnostics in Latin America, including HPV DNA testing, and 3) Assessment of opportunities for introduction of HPV DNA testing in three African countries and development of introduction strategies, where feasible.