NCI is collaborating with investigators at the German Cancer Research Center and the International Agency for Research on Cancer (IARC) in France to study head and neck cancers within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC was designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors and the incidence of cancer and other chronic diseases. Investigators will prospectively evaluate the risk conferred by human papillomavirus (HPV) serostatus detected prior to diagnosis of cancers at multiple anatomic sites in the head and neck.