NCI investigators are participating as members of the international Melanoma Genetics Consortium (GenoMEL), along with multiple investigators from the U.S., Australia, Canada, Israel, and Europe to create the largest familial melanoma study population to characterize mutations in high-risk melanoma susceptibility genes. Investigators are collecting consistent exposure information to evaluate the interaction of environmental exposures including sun exposure and CDKN2A mutation status across the different countries. GenoMEL is also investigating low risk susceptibility genes for melanoma using a case-control approach.  Recently, NCI investigators have participated in several GenoMEL genome-wide association studies that have identified loci associated with melanoma risk.